Conservatives won a big victory in the off-year election in Ohio on Tuesday with a huge win on the issue of ObamaCare.

Ohio voters overwhelmingly approved a state constitutional amendment disapproving the federal mandate that will require most Americans to buy health insurance by 2014 or face fines.

The Ohio referendum called Issue 3 won with a whopping 66% of the vote.

This is yet another significant repudiation of the Obama agenda, and the first electoral defeat for Obama's national health care plan since it was signed into law in March 2010.